{"product_id":"erk-1-2-monoclonal-antibody-e-ab-22142","title":"ERK 1\/2 Monoclonal Antibody - E-AB-22142","description":"\u003cp\u003eERK 1\/2 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-22142-60, E-AB-22142-120, E-AB-22142-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: ERK1\/2 Mouse (1H4)\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: MAPK3; ERK1; PRKM3; Mitogen-activated protein kinase 3; MAP kinase 3; MAPK 3; ERT2; Extracellular signal-regulated kinase 1; ERK-1; Insulin-stimulated MAP2 kinase; MAP kinase isoform p44; p44-MAPK; Microtubule-associated protein 2 kinase; p\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer,Signal Transduction,Neuroscience\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB, IHC-p\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone No.: Clone:7D3\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P27361,P28482\u003c\/p\u003e\n\n\u003cp\u003eBackground: Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1 (By similarity). Phosphorylates heat shock factor protein 4 (HSF4) and ARHGEF2.Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic Peptide of ERK1\/2\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Protein A purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:1000-2000, IHC 1:100-200\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 44,42kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43148620169395,"sku":"E-AB-22142-60","price":200.2,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43148620202163,"sku":"E-AB-22142-120","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43148620234931,"sku":"E-AB-22142-200","price":558.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_52ce42b3-c417-478b-8ad4-35b0aa9ca714.png?v=1710326860","url":"https:\/\/afsbio.com\/products\/erk-1-2-monoclonal-antibody-e-ab-22142","provider":"AFSBio Inc.","version":"1.0","type":"link"}