{"product_id":"errγ-polyclonal-antibody-gcp51","title":"ERRγ Polyclonal Antibody-GCP51","description":"\u003cp\u003eERRγ Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: GCP51-50, GCP51-100\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P62508\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB: 1:1000~1:2000\u003c\/p\u003e\n\n\u003cp\u003eBackground: ERRβ\/γ Antibody (E-1) is a high quality monoclonal ERRβ\/γ antibody (also designated ERRβ\/γ antibody) suitable for the detection of the ERRβ\/γ protein of mouse, rat and human origin. ERRβ\/γ Antibody (E-1) is available as both the non-conjugated anti-ERRβ\/γ antibody form, as well as multiple conjugated forms of anti-ERRβ\/γ antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Estrogen and progesterone receptors are members of a family of transcription factors that are regulated by the binding of their cognate ligands. The interaction of hormone-bound estrogen receptors with estrogen responsive elements (EREs) alters transcription of ERE-containing genes. Estrogen receptor-related proteins (ERRα, β and γ) are orphan nuclear receptors. Like estrogen receptors, ERRs bind specifically to EREs to activate reporter genes. ERRβ, also known as steroid hormone receptor ERR2 or estrogen receptor-like 2, is expressed during mammary gland development and is critical in embryo development. The loss of ERRβ results in severely impaired chorion formation leading to placental failure and embryonic death. ERRβ also potently represses the transcriptional activity of Nrf2. ERRγ, also known as ERR3, is abundantly expressed in fetal heart. The loss of ERRγ results in lactatemia and death within the first week of life.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: ERRγ polyclonal antibody detects endogenous levels of ERRγ protein.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot (WB) analysis of ERRγ polyclonal antibody at 1:1000 dilution\u003cbr\u003e\nLane1:A549 whole cell lysate(40ug)\u003cbr\u003e\nLane2:SGC7901 whole cell lysate(40ug)\u003cbr\u003e\nLane3:Pancl whole cell lysate(40ug)\u003cbr\u003e\nLane4:HCT116 whole cell lysate(40ug)\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 60 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Estrogen-related receptor gamma; ERR gamma-2; Estrogen receptor-related protein 3; Nuclear receptor subfamily 3 group B member 3; ESRRG; ERR3;  ERRG2; KIAA0832; NR3B3\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide, corresponding to Human ERRγ.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42908756017331,"sku":"GCP51-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42908756050099,"sku":"GCP51-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_7554b392-db58-4c76-ae63-b1928d01665e.jpg?v=1703006693","url":"https:\/\/afsbio.com\/products\/err%ce%b3-polyclonal-antibody-gcp51","provider":"AFSBio Inc.","version":"1.0","type":"link"}