{"product_id":"est1-rabbit-polyclonal-antibody-bt-ap09762","title":"EST1 Rabbit Polyclonal Antibody - BT-AP09762","description":"\u003cp\u003eEST1 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP09762-20, BT-AP09762-50, BT-AP09762-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics| such as cocaine and heroin| and endogenous substrates with ester| thioester| or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism| and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene.\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Cardiovascular; Metabolism; Signal transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: CES1\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: EST1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P23141; Mouse: Q8VCC2\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: EST1; Liver carboxylesterase 1; Acyl-coenzyme A:cholesterol acyltransferase; ACAT; Brain carboxylesterase hBr1; Carboxylesterase 1; CE-1; hCE-1; EC 3.1.1.1; Cocaine carboxylesterase; Egasyn; HMSE; Methylumbelliferyl-acetate deacetylase 1; EC 3.1.1.56; Monocyte\/macrophage serine esterase; Retinyl ester hydrolase; REH; Serine esterase 1; Triacylglycerol hydrolase; TGH)\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 1066; Mouse: 12623\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45238994600115,"sku":"BT-AP09762-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45238994632883,"sku":"BT-AP09762-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238994665651,"sku":"BT-AP09762-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_17883668-3229-4cb9-91c0-d3ed01849c60.png?v=1769387680","url":"https:\/\/afsbio.com\/products\/est1-rabbit-polyclonal-antibody-bt-ap09762","provider":"AFSBio Inc.","version":"1.0","type":"link"}