{"product_id":"est3-rabbit-polyclonal-antibody-es16669","title":"EST3 Rabbit Polyclonal Antibody - ES16669","description":"\u003cp\u003eEST3 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES16669-50, ES16669-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene is expressed in several tissues, particularly in colon, trachea and in brain, and the protein participates in colon and neural drug metabolism. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported, but the biological validity and\/or full-length nature of some variants have not been determined.[provided by RefSeq, Jun 2010],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse,\u003c\/p\u003e \n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: Carboxylesterase 3 (EC 3.1.1.1) (Liver carboxylesterase 31 homolog)\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from human EST3 AA range: 447-497\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: EST3\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: This antibody detects endogenous levels of EST3 at Human\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.193% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Expressed in liver, colon and small intestine,\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 65kD\u003c\/p\u003e\n\n\u003cp\u003eFunction: Catalytic Activity: A carboxylic ester + H(2)O = an alcohol + a carboxylate\u003cbr\u003e\nFunction: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics\u003cbr\u003e\nPTM: N-glycosylated\u003cbr\u003e\nSimilarity: Belongs to the type-B carboxylesterase\/lipase family\u003cbr\u003e\nTissue Specificity: Expressed in liver, colon and small intestine\u003c\/p\u003e\n\n\n\u003cp\u003eSubcellular Location: Endoplasmic reticulum lumen\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: CES3 UNQ869\/PRO1887\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: EST3\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46315461574835,"sku":"ES16669-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46315461607603,"sku":"ES16669-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies.jpg?v=1793190497","url":"https:\/\/afsbio.com\/products\/est3-rabbit-polyclonal-antibody-es16669","provider":"AFSBio Inc.","version":"1.0","type":"link"}