{"product_id":"estrogen-receptor-α-rabbit-polyclonal-antibody-es20757","title":"Estrogen Receptor α Rabbit Polyclonal Antibody - ES20757","description":"\u003cp\u003eEstrogen Receptor α Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES20757-50, ES20757-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Mar 2014],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant Protein of Estrogen Receptor α\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: Estrogen Receptor-α\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: The antibody detects endogenous Estrogen Receptor α protein\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB: 1:500-1:2000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Widely expressed (PubMed:10970861), Not expressed in the pituitary gland (PubMed:10970861),, [Isoform 3]: Widely expressed, however not expressed in the pituitary gland,\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 66kD\u003c\/p\u003e\n\n\u003cp\u003eFields: Endocrine resistance, Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Endocrine and other factor-regulated calcium reabsorption, Pathways in cancer, Proteoglycans in cancer, Chemical carcinogenesis - receptor activation, Breast cancer\u003c\/p\u003e\n\n\u003cp\u003eFunction: Domain: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain\u003cbr\u003e\nFunction: Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues\u003cbr\u003e\nOnline Information: Estrogen receptor entry,polymorphism: Genetic variations in ESR1 are correlated with bone mineral density (BMD). Low BMD is a risk factor for osteoporotic fracture. Osteoporosis is characterized by reduced bone mineral density, disrutption of bone microarchitecture, and the alteration of the amount and variety of non-collagenous proteins in bone. Osteoporotic bones are more at risk of fracture\u003cbr\u003e\nPTM: Glycosylated, contains N-acetylglucosamine, probably O-linked\u003cbr\u003e\nPTM: Phosphorylated by cyclin A\/CDK2. Phosphorylation probably enhances transcri\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: [Isoform 1]: Nucleus Cytoplasm Cell membrane, Peripheral membrane protein, Cytoplasmic side A minor fraction is associated with the inner membrane, [Isoform 3]: Nucleus Cytoplasm Cell membrane, Peripheral membrane protein, Cytoplasmic side Cell membrane, Single-pass type I membrane protein Associated with the inner membrane via palmitoylation (Probable) At least a subset exists as a transmembrane protein with a N-terminal extracellular domain, Nucleus Golgi apparatus Cell membrane Colocalizes with ZDHHC7 and ZDHHC21 in the Golgi apparatus where most probably palmitoylation occurs Associated with the plasma membrane when palmitoylated\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: ESR1\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: P19785\u003c\/p\u003e\n\n\u003cp\u003eRat SwissProt Number: P06211\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46314186899635,"sku":"ES20757-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46314186932403,"sku":"ES20757-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies_d75295e2-ffc1-4e0f-a3e7-87715c8983a9.jpg?v=1793190507","url":"https:\/\/afsbio.com\/products\/estrogen-receptor-%ce%b1-rabbit-polyclonal-antibody-es20757","provider":"AFSBio Inc.","version":"1.0","type":"link"}