{"product_id":"estrogen-receptor-alpha-monoclonal-antibody-mb66133","title":"Estrogen Receptor alpha Monoclonal Antibody - MB66133","description":"\u003cp\u003eEstrogen Receptor alpha Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μl, 100μl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: MB66133-50, MB66133-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: Estrogen receptor α (ERα), a member of the steroid receptor superfamily, contains highly conserved DNA binding and ligand binding domains . Through its estrogen-independent and estrogen-dependent activation domains (AF-1 and AF-2, respectively), ERα regμlates transcription by recruiting coactivator proteins and interacting with general transcriptional machinery. Phosphorylation at mμltiple sites provides an important mechanism to regμlate ERα activity . Ser104, 106, 118, and 167 are located in the amino-terminal transcription activation function domain AF-1, and phosphorylation of these serine residues plays an important role in regμlating ERα activity. Ser118 may be the substrate of the transcription regμlatory kinase CDK7 . Ser167 may be phosphorylated by p90RSK and Akt . According to the research literature, phosphorylation at Ser167 may confer tamoxifen resistance in breast cancer patients .\u003c\/p\u003e\n\n\u003cp\u003eCategory: Primary Antibody\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: ESR, NR3A1, Estrogen receptor, ER, ER-alpha, Estradiol receptor, Nuclear receptor subfamily 3 group A member 1\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodification\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: KLH-conjugated synthetic peptide encompassing a sequence within human Estrogen Receptor alpha. The exact sequence is proprietary.\u003c\/p\u003e\n\n\u003cp\u003eDilution: IHC (1\/100 - 1\/300)\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Recognizes endogenous levels of Estrogen Receptor alpha protein.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: ~ 66 kDa\u003c\/p\u003e\n\n\u003cp\u003ePathway: MAPK Erk in Growth and Differentiation Pathway,\u003c\/p\u003e \n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSwissProt: P03372\u003c\/p\u003e\n\n\u003cp\u003eProduct: Mouse IgG2b. Liquid in PBS containing 50% glycerol, 0.2% BSA and 0.01% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"50μl","offer_id":45946395754675,"sku":"MB66133-50","price":274.5,"currency_code":"CAD","in_stock":true},{"title":"100μl","offer_id":45946395787443,"sku":"MB66133-100","price":457.5,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Bioworld_Antibody_Image_6ca33534-2486-4e91-ac84-9e0d75778258.jpg?v=1788363539","url":"https:\/\/afsbio.com\/products\/estrogen-receptor-alpha-monoclonal-antibody-mb66133","provider":"AFSBio Inc.","version":"1.0","type":"link"}