{"product_id":"estrogen-receptor-alpha-polyclonal-antibody-e-ab-60073","title":"Estrogen Receptor alpha Polyclonal Antibody - E-AB-60073","description":"\u003cp\u003eEstrogen Receptor alpha Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-60073-60, E-AB-60073-120, E-AB-60073-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: Estrogen Receptor alpha\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: ESR1; ER; ESR; ESRA; ESTRR; Era; NR3A1; ER alpha\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Epigenetics and Nuclear Signaling, Neuroscience, Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: P03372\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human Estrogen Receptor alpha (NP_000116.2).\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB \t1:1000-1:4000\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 35kDa\/47kDa\/53kDa\/66kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 75kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146039591091,"sku":"E-AB-60073-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146039623859,"sku":"E-AB-60073-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146039656627,"sku":"E-AB-60073-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_fc6f8596-e97e-475b-876e-23755fe99641.png?v=1710290373","url":"https:\/\/afsbio.com\/products\/estrogen-receptor-alpha-polyclonal-antibody-e-ab-60073","provider":"AFSBio Inc.","version":"1.0","type":"link"}