{"product_id":"estrogen-receptor-beta-phospho-s105-polyclonal-antibody-bs64525","title":"Estrogen Receptor beta (Phospho-S105) Polyclonal Antibody-BS64525","description":"\u003cp\u003eEstrogen Receptor beta (Phospho-S105) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS64525-50, BS64525-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q92731\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, IF\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB:1:500~1:1000 IHC:1:50~1:200 IF:1:50~1:200\u003c\/p\u003e\n\n\u003cp\u003eBackground: Estrogen receptors (ER) are members of the steroid\/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including ERα and ERβ, contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of reproductive tissues. ERα and ERβ have been shown to be differentially activated by various ligands. Receptor-ligand interactions trigger a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes. Evidence suggests that ERα and ERβ may be regulated by distinct mechanisms even though they share many functional characteristics.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Estrogen Receptor beta (Phospho-S105) polyclonal antibody detects endogenous levels of Estrogen Receptor beta protein only when phosphorylated at Ser105.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 59 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot (WB) analysis of Estrogen Receptor beta (Phospho-S105) polyclonal antibody at 1:500 dilution\u003cbr\u003e\nLane A: HEK293T whole cell lysate\u003cbr\u003e\nLane B: Hela whole cell lysate\u003cbr\u003e\nLane C: A375 whole cell lysate\u003cbr\u003e\nLane D: The Spleen tissue lysate of Mouse\u003cbr\u003e\nLane E: The Spleen tissue lysate of Rat\u003cbr\u003e\nLane F: The Testis tissue lysate of Rat\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Estrogen receptor beta; ER-beta; Nuclear receptor subfamily 3 group A member 2; ESR2; ESTRB; NR3A2; ER-β\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic phosphopeptide derived from human Estrogen Receptor beta around the phosphorylation site of Serine 105.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Phosphorylation\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":43044028907699,"sku":"BS64525-50","price":342.59,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":43044028940467,"sku":"BS64525-100","price":589.65,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_a318a0ae-159c-4505-9d9c-5a13710fec8f.jpg?v=1707738666","url":"https:\/\/afsbio.com\/products\/estrogen-receptor-beta-phospho-s105-polyclonal-antibody-bs64525","provider":"AFSBio Inc.","version":"1.0","type":"link"}