{"product_id":"ets1-monoclonal-antibody-mb66887","title":"ETS1 Monoclonal Antibody - MB66887","description":"\u003cp\u003eETS1 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μl, 100μl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: MB66887-50, MB66887-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: ETS-1 is a proto-oncoprotein that belongs to the E26 Transformation-specific Sequence family of transcription factors that share a unique and highly conserved DNA binding domain . ETS-1 plays important roles in vascμlar development and angiogenesis, and vascμlar inflammation and remodeling . The target genes of ETS-1 include receptor tyrosine kinases, MMPs, and cell adhesion molecμles . In addition, ETS-1 is involved in regμlation of energy metabolism in cancer cells . ETS-1 activity is regμlated by two different types of phosphorylation sites. While phosphorylation at a cluster of serine residues in the exon VII domain by CaMKII inhibits ETS-1 DNA binding activity , phosphorylation at its Thr38 site by Ras activates ETS-1 .\u003c\/p\u003e\n\n\u003cp\u003eCategory: Primary Antibody\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, FC\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: EWSR2, Protein C-ets-1, p54\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodification\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human ETS1. The exact sequence is proprietary.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB (1\/500 - 1\/1000), IF\/ICC (1\/10 - 1\/50)\u003c\/p\u003e\n\n\u003cp\u003ePurification: This antibody is purified through a protein G column.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Recognizes endogenous levels of ETS1 protein.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: ~ 56 kDa\u003c\/p\u003e\n\n\u003cp\u003ePathway: T cell receptor signaling, G Protein-coupled Receptors Signaling to MAPK Erk, Signaling Pathways Activating p38 MAP Kinase\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSwissProt: P14921\u003c\/p\u003e\n\n\u003cp\u003eProduct: Mouse IgG2b kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"50μl","offer_id":45946422821043,"sku":"MB66887-50","price":274.5,"currency_code":"CAD","in_stock":true},{"title":"100μl","offer_id":45946422853811,"sku":"MB66887-100","price":457.5,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Bioworld_Antibody_Image_6ca33534-2486-4e91-ac84-9e0d75778258.jpg?v=1788363539","url":"https:\/\/afsbio.com\/products\/ets1-monoclonal-antibody-mb66887","provider":"AFSBio Inc.","version":"1.0","type":"link"}