Everolimus BSA Conjugate (0.5 mg)
Everolimus BSA Conjugate (0.5 mg)
Everolimus BSA Conjugate (0.5 mg)

Everolimus BSA Conjugate (0.5 mg)

Regular price
$783.91
Regular price
Sale price
$783.91
Unit price
per 
Availability
Sold out

Concentrated solution of Bovine Serum Albumin (BSA) conjugated to Everolimus. A carbon spacer arm of 19.0 Å links BSA to the Everolimus moiety. Each BSA molecule contains several Everolimus units. Dilutions of the provided conjugate can be made in 1X Phosphate Buffer Saline, pH 7.4.

 

Product Data Sheet Download PDF
MSDS Download PDF
Catalog number: P2010024
Lot number: 0120P0024
Expiration date: 2024-02
Purity: > 95%
Concentration: 1 mg/mL
Package Size: 0.5 mg
Molecular Weight: 71 kDa (average)
Storage: -20°C. Avoid repeated freeze/thaw cycles.
Other names: BSA-Everolimus, Everolimus-BSA, BSA conjugated to Everolimus, 40-O-(2-hydroxyethyl)-sirolimus BSA, Everolimus Bovine Serum Albumin Conjugate, Everolimus [BSA].
Keywords: BSA conjugate, Everolimus, Certican, Zortress, Afinitor, Votubia, Evertor.
Buffer: 1X Phosphate Buffer Saline, pH 7.4.

 

About Everolimus

Everolimus is a synthetic derivative of the natural compound sirolimus (40-O-(2-hydroxyethyl)-sirolimus). Everolimus has both immunosuppressant and anti-angiogenic properties. As a result, this molecule finds several applications in organ transplant as well as chemotherapy. Inside the cell, Everolimus inhibits the activation of the mammalian target of Rapamycin (sirolimus) (mTOR).

 

References

  1. Montero N, Pascual J. Immunosuppression and Post-transplant Hyperglycemia. Curr Diabetes Rev. 2015;11(3):144-54.
  2. Everolimus. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-2018 Feb 26.
  3. Guan TW, Lin YJ, Ou MY, Chen KB. Efficacy and safety of everolimus treatment on liver transplant recipients: A meta-analysis. Eur J Clin Invest. 2019 Dec;49(12):e13179.
  4. Hasskarl J. Everolimus. Recent Results Cancer Res. 2018;211:101-123.
  5. Moes DJ, Guchelaar HJ, de Fijter JW. Sirolimus and everolimus in kidney transplantation. Drug Discov Today. 2015 Oct;20(10):1243-9.