{"product_id":"ews-polyclonal-antibody-bt-ap03101","title":"EWS Polyclonal Antibody - BT-AP03101","description":"\u003cp\u003eEWS Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP03101-20, BT-AP03101-50, BT-AP03101-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: EWSR1 encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically at (11;22) (q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Tags and Cell Markers\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: EWSR1\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: EWS Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 68478\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q01844; Mouse: Q61545\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: EWSR1; EWS; RNA-binding protein EWS; EWS oncogene; Ewing sarcoma breakpoint region 1 protein\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 2130; Mouse: 14030\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45240297947315,"sku":"BT-AP03101-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45240297980083,"sku":"BT-AP03101-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45240298012851,"sku":"BT-AP03101-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_e1a8c6be-ed68-497f-9bc9-dc74e03f8014.png?v=1769406416","url":"https:\/\/afsbio.com\/products\/ews-polyclonal-antibody-bt-ap03101","provider":"AFSBio Inc.","version":"1.0","type":"link"}