{"product_id":"fa12heavy-chain-cleaved-ile20polyclonal-antibody-bs65134","title":"FA12(heavy Chain,Cleaved-Ile20)Polyclonal Antibody-BS65134","description":"\u003cp\u003eFA12(heavy Chain,Cleaved-Ile20)Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eProduct: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS65134-50, BS65134-100\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P00748\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB,IHC-p,If (paraffin section),ELISA\u003c\/p\u003e\n\n\u003cp\u003eBackground: coagulation factor XIi (F12) Homo sapiens This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activat\u003c\/p\u003e\n\n\u003cp\u003eProduct: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Cleaved-Factor XII HC (I20) Polyclonal Antibody detects endogenous levels of fragment of activated Factor XII HC protein resulting from cleavage adjacent to I20.\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot analysis of FA12 (heavy chain, Cleaved-Ile20) Antibody. The lane on the right is blocked with the FA12 (heavy chain, Cleaved-Ile20) peptide., Immunohistochemistryt analysis of paraffin-embedded human lung carcinoma, using FA12 (heavy chain, Cleaved-Ile20) Antibody. The lane on the right is blocked with the FA12 (heavy chain, Cleaved-Ile20) peptide.\u003c\/p\u003e \n\n\u003cp\u003eBioworld Molecular Weight: ~ 41 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: F12; Coagulation factor XII; Hageman factor; HAF\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human FA12. AA range:1-50\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Cleaved\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42949515215027,"sku":"BS65134-50","price":254.38,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42949515247795,"sku":"BS65134-100","price":442.75,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_79636102-b449-4077-b8c8-d8c25445c6e6.jpg?v=1704971022","url":"https:\/\/afsbio.com\/products\/fa12heavy-chain-cleaved-ile20polyclonal-antibody-bs65134","provider":"AFSBio Inc.","version":"1.0","type":"link"}