{"product_id":"fadd-monoclonal-antibody-bt-mca2731","title":"FADD Monoclonal Antibody - BT-MCA2731","description":"\u003cp\u003eFADD Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA2731-50, BT-MCA2731-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6\/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10\/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cell Biology\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: FADD\u003c\/p\u003e\n\n\u003cp\u003eApplications: FCM\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 5A6A2\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG1\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: FADD\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of human FADD (AA: 20-150) expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Purified antibody in PBS with 0.05% sodium azide\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 23.3kDa\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Q13158\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: GIG3, MORT1\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 8772\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238414114995,"sku":"BT-MCA2731-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238414147763,"sku":"BT-MCA2731-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_5daa25c4-7757-43ba-ae66-719e792f0d98.png?v=1769380335","url":"https:\/\/afsbio.com\/products\/fadd-monoclonal-antibody-bt-mca2731","provider":"AFSBio Inc.","version":"1.0","type":"link"}