{"product_id":"fadd-rabbit-polymab®-a26418pm","title":"FADD Rabbit PolymAb® - A26418PM","description":"\u003cp\u003eFADD Rabbit PolymAb®\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: A26418PM-20, A26418PM-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Predicted to enable several functions, including caspase binding activity; death effector domain binding activity; and tumor necrosis factor receptor superfamily binding activity. Involved in several processes, including hematopoietic or lymphoid organ development; negative regulation of activation-induced cell death of T cells; and positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation. Acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand; motor neuron apoptotic process; and regulation of programmed cell death. Predicted to be located in several cellular components, including cell body; cytosol; and membrane raft. Predicted to be part of CD95 death-inducing signaling complex and ripoptosome. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Human ortholog (s) of this gene implicated in leukemia. Orthologous to human FADD (Fas associated via death domain) .\u003c\/p\u003e\n\n\u003cp\u003eCategory: Monoclonal Antibodies\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IP, IHC-P, ELISA\u003c\/p\u003e\n\n\u003cp\u003eCross-reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eProtein Weight: 23kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved Molecular Weight: 28kDa\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant protein (or fragment) .\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\/Mouse\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 14082\/8772\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q61160\/Q13158\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: Mort1\/FADD\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003ePurity: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20℃. Avoid freeze \/ thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.\u003c\/p\u003e\n\n\u003cp\u003eRecommended Dilutions: WB, 1:4500 - 1:15000 IP, 0.5μg-4μg antibody for 200μg-400μg extracts of whole cells IHC-P, 1:1000 - 1:4000 ELISA, Recommended starting concentration is 1 μg\/mL. Please optimize the concentration based on your specific assay requirements.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cell Biology Apoptosis Intracellular Associated ProteinsCancer Invasion\/microenvironment Apoptosis Death receptors \u0026amp; ligands FADDCancer Cell Death Apoptosis Receptors Death receptors \u0026amp; ligands FADDCancer Cell Death Necroptosis\u003c\/p\u003e\n\n\u003cp\u003eNCBI Alias: Fadd\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"20uL","offer_id":45189881397427,"sku":"A26418PM-20","price":165.2,"currency_code":"CAD","in_stock":true},{"title":"100uL","offer_id":45189881430195,"sku":"A26418PM-100","price":431.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_c2a43d1c-ec11-48b3-9cc5-69515daf6bd6.png?v=1766437360","url":"https:\/\/afsbio.com\/products\/fadd-rabbit-polymab%c2%ae-a26418pm","provider":"AFSBio Inc.","version":"1.0","type":"link"}