{"product_id":"fan-rabbit-polyclonal-antibody-es16527","title":"FAN Rabbit Polyclonal Antibody - ES16527","description":"\u003cp\u003eFAN Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES16527-50, ES16527-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a WD-repeat protein that binds the cytoplasmic sphingomyelinase activation domain of the 55kD tumor necrosis factor receptor. This protein is required for TNF-mediated activation of neutral sphingomyelinase and may play a role in regulating TNF-induced cellular responses such as inflammation. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from human FAN AA range: 147-197\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: FAN\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: This antibody detects endogenous levels of FAN at Human\/Mouse\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1：500-2000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Ubiquitous,\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 101kD\u003c\/p\u003e\n\n\u003cp\u003eFields: Sphingolipid signaling pathway\u003c\/p\u003e\n\n\u003cp\u003eFunction: Function: Couples the p55 TNF-receptor (TNF-R55 \/ TNFR1) to neutral sphingomyelinase (N-SMASE). Specifically binds to the N-smase activation domain of TNF-R55. May regulate ceramide production by N-SMASE\u003cbr\u003e\nSimilarity: Contains 1 BEACH domain\u003cbr\u003e\nSimilarity: Contains 1 GRAM domain\u003cbr\u003e\nSimilarity: Contains 6 WD repeats\u003cbr\u003e\nTissue Specificity: Ubiquitous\u003c\/p\u003e\n\n\n\u003cp\u003eSubcellular Location: cytoplasm, cytosol, endomembrane system, extrinsic component of membrane,\u003c\/p\u003e \n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: NSMAF FAN\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: FAN\u003c\/p\u003e\n\n\u003cp\u003eMouse Gene ID: 18201\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: O35242\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46315424284851,"sku":"ES16527-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46315424317619,"sku":"ES16527-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies.jpg?v=1793190497","url":"https:\/\/afsbio.com\/products\/fan-rabbit-polyclonal-antibody-es16527","provider":"AFSBio Inc.","version":"1.0","type":"link"}