{"product_id":"fas-monoclonal-antibody-bt-mca2359","title":"FAS Monoclonal Antibody - BT-MCA2359","description":"\u003cp\u003eFAS Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA2359-50, BT-MCA2359-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3\/ERK1, and MAPK8\/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cell Biology\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: FAS\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, FCM\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 4F8D6\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG1\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: FAS\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of human FAS expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Purified antibody in PBS with 0.05% sodium azide\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 37.7kDa\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: P25445\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: APT1, CD95, FAS1, APO-1, FASTM, ALPS1A, TNFRSF6\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 355\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238585098419,"sku":"BT-MCA2359-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238585131187,"sku":"BT-MCA2359-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_f8d4d3e6-9157-4ea9-9579-e0a155ec022b.png?v=1769382823","url":"https:\/\/afsbio.com\/products\/fas-monoclonal-antibody-bt-mca2359","provider":"AFSBio Inc.","version":"1.0","type":"link"}