{"product_id":"fbln5-polyclonal-antibody-e-ab-63037","title":"FBLN5 Polyclonal Antibody - E-AB-63037","description":"\u003cp\u003eFBLN5 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-63037-60, E-AB-63037-120, E-AB-63037-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: FBLN5\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: FBLN5; ADCL2; ARCL1A; ARMD3; DANCE; EVEC; FIBL-5; HNARMD; UP50; fibulin-5\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cardiovascular, Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB, IF\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: Q9UBX5\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3).\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human FBLN5 (NP_006320.2).\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB \t1:500-1:2000   IF \t1:50-1:100\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 50kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 72kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146273489075,"sku":"E-AB-63037-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146273521843,"sku":"E-AB-63037-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146273554611,"sku":"E-AB-63037-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_eb49cd96-b6ea-4200-9d36-e3d6b6add745.png?v=1710292786","url":"https:\/\/afsbio.com\/products\/fbln5-polyclonal-antibody-e-ab-63037","provider":"AFSBio Inc.","version":"1.0","type":"link"}