{"product_id":"ffar3-polyclonal-antibody-e-ab-90435","title":"FFAR3 Polyclonal Antibody - E-AB-90435","description":"\u003cp\u003eFFAR3 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-90435-60, E-AB-90435-120, E-AB-90435-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: FFAR3\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: FFAR3; FFA3R; GPR41; GPR42\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: O14843\u003c\/p\u003e\n\n\u003cp\u003eBackground: G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs, and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i\/o-alpha family of G proteins. Its activation results in the formation of inositol 1, 4, 5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3\/ERK1 and MAPK1\/ERK2 kinases and the inhibition of intracellular cAMP accumulation. Activated by SCFAs and by beta-hydroxybutyrate, a ketone body produced by the liver upon starvation, it inhibits N-type calcium channels and modulates the activity of sympathetic neurons through a signaling cascade involving the beta and gamma subunits of its coupled G protein, phospholipase C and MAP kinases. Thereby, it may regulate energy expenditure through the control of the sympathetic nervous system that controls for instance heart rate.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human FFAR3\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.01% thiomersal, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-1:2000\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 38kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 39KDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43148722667699,"sku":"E-AB-90435-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43148722700467,"sku":"E-AB-90435-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43148722733235,"sku":"E-AB-90435-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_3b368d62-c8e8-489a-86e5-53abfccedaa0.png?v=1710328761","url":"https:\/\/afsbio.com\/products\/ffar3-polyclonal-antibody-e-ab-90435","provider":"AFSBio Inc.","version":"1.0","type":"link"}