{"product_id":"fgd1-rabbit-polyclonal-antibody-bt-ap10026","title":"FGD1 Rabbit Polyclonal Antibody - BT-AP10026","description":"\u003cp\u003eFGD1 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP10026-20, BT-AP10026-50, BT-AP10026-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a protein that contains Dbl (DH) and pleckstrin (PH) homology domains and is similar to the Rho family of small GTP-binding proteins. The encoded protein specifically binds to the Rho family GTPase Cdc42Hs and can stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK\/JNK1 activation. Defects in this gene are the cause of faciogenital dysplasia and X-linked mental retardation| syndromatic 16.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: FGD1\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: FGD1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P98174; Mouse: P52734\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: FGD1; FYVE; RhoGEF and PH domain-containing protein 1; Faciogenital dysplasia 1 protein; Rho\/Rac guanine nucleotide exchange factor FGD1; Rho\/Rac GEF; Zinc finger FYVE domain-containing protein 3)\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 2245; Mouse: 14163\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45238995583155,"sku":"BT-AP10026-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45238995615923,"sku":"BT-AP10026-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238995648691,"sku":"BT-AP10026-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_ee43ec19-1c06-4420-b8ba-cc371e366061.png?v=1769387697","url":"https:\/\/afsbio.com\/products\/fgd1-rabbit-polyclonal-antibody-bt-ap10026","provider":"AFSBio Inc.","version":"1.0","type":"link"}