{"product_id":"fgfr2-cd332-mouse-monoclonal-antibody-mb9029","title":"FGFR2\/CD332 Mouse Monoclonal Antibody-MB9029","description":"\u003cp\u003eFGFR2\/CD332 Mouse Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: MB9029-50, MB9029-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Mouse IgG1, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P21802\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ICC IHC\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB: 1:500 \u003cbr\u003e\nIHC\/ICC: 1:100-1:200\u003c\/p\u003e\n\n\u003cp\u003eBackground: Fibroblast growth factor receptor 2 (FGFR2) also known as CD332 has two naturally occurring isoforms FGFR2IIIb and FGFR2IIIc, created by splicing of the third immunoglobulin-like domain. FGFR2IIIb is predominantly found in ectoderm derived tissues and endothelial organ lining, i.e. skin and internal organs. FGFR2 has important roles in embryonic development and tissue repair, especially bone and blood vessels. Like the other members of the Fibroblast growth factor receptor family, these receptors signal by binding to their ligand and dimerisation (pairing of receptors), which causes the tyrosine kinase domains to initiate a cascade of intracellular signals. As mentioned, FGFR2 mutations are associated with craniosynostosis syndromes, which are skull malformations caused by premature fusion of cranial sutures and other disease features according to the mutation itself.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: Protein A affinity purified\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: This antibody detects endogenous levels of FGFR2 and does not cross-react with related proteins.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: Predicted band size: 92 KDa \u003cbr\u003e\nObserved band size: 100, 150 KDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot (WB) analysis of FGFR2 Mouse mAb at 1:500 dilution\u003cbr\u003e\n Lane 1: MCF7 whole cell lysate\u003cbr\u003e\n Lane 2: K562 whole cell lysate\u003cbr\u003e\n Lane 3: Hela whole cell lysate\u003cbr\u003e\n Lane 4: HepG2 whole cell lysate\u003cbr\u003e\n Lane 5: A431 whole cell lysate\u003cbr\u003e\n Lane 6: A549 whole cell lysate\u003cbr\u003e\n Lane 7: NIH\/3T3 whole cell lysate\u003cbr\u003e\n Lane 8: Jurkat whole cell lysate, Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-FGFR2 antibody. Counter stained with hematoxylin., ICC staining of FGFR2 in MCF-7 cells (red). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton *100\/PBS.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Fibroblast growth factor receptor 2; FGFR-2; K-sam; KGFR; Keratinocyte growth factor receptor; CD332; FGFR2; BEK; KGFR; KSAM\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: This antibody is produced by immunizing mice with a recombinant protein corresponding to a region of FGFR2.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":43044037165235,"sku":"MB9029-50","price":424.94,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":43044037198003,"sku":"MB9029-100","price":655.54,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_3bf47c0c-7b21-4c4e-bd44-da8c5b500b47.jpg?v=1707738856","url":"https:\/\/afsbio.com\/products\/fgfr2-cd332-mouse-monoclonal-antibody-mb9029","provider":"AFSBio Inc.","version":"1.0","type":"link"}