{"product_id":"fh-fumarase-monoclonal-antibody-2b11-bt-mca0536","title":"FH Fumarase Monoclonal Antibody (2B11) - BT-MCA0536","description":"\u003cp\u003eFH Fumarase Monoclonal Antibody (2B11)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-MCA0536-20, BT-MCA0536-50, BT-MCA0536-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. It is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal transduction; Cancer; Metabolism\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: FH\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IF, ICC\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human,Mouse,Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Fumarate hydratase, mitochondrial\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P07954; Mouse: P97807; Rat: P14408\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Fumarate hydratase; mitochondrial\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 2271; Mouse: 14194\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45240037310643,"sku":"BT-MCA0536-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45240037343411,"sku":"BT-MCA0536-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45240037376179,"sku":"BT-MCA0536-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_888cada3-3f30-4249-acaf-4f51564a3968.png?v=1769402498","url":"https:\/\/afsbio.com\/products\/fh-fumarase-monoclonal-antibody-2b11-bt-mca0536","provider":"AFSBio Inc.","version":"1.0","type":"link"}