{"product_id":"finetest®488-anti-mouse-cd122-il-2rb-antibody-5h4-f488-30213u","title":"FineTest®488 Anti-Mouse CD122\/IL-2RB Antibody (5H4) - F488-30213U","description":"\u003cp\u003eFineTest®488 Anti-Mouse CD122\/IL-2RB Antibody (5H4)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 25μg, 100μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: F488-30213U-25, F488-30213U-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eTarget: Mouse CD122\/IL-2RB\u003c\/p\u003e\n\n\u003cp\u003eForm: Liquid\u003c\/p\u003e\n\n\u003cp\u003eConjugation: FineTest®488\u003c\/p\u003e\n\n\u003cp\u003eConjugation Information: FineTest® 488 is designed to be excited by the Blue laser (488 nm) and detected using an optical filter centered near 520 nm (e.g., a 525\/40 nm bandpass filter).\u003c\/p\u003e\n\n \n\n \n\n\n\n\u003cp\u003eHost: Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 5H4\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG2a, κ\u003c\/p\u003e\n\n\u003cp\u003eStorage: PBS with 0. 1% sodium azide, 1%BSA, pH 7.3, 2-8℃ for 12 months (Avoid repeated freeze \/ thaw cycles.)\u003c\/p\u003e\n\n\u003cp\u003eBackground: CD122 is a 70-75 kD IL-2 receptor β chain also known as IL-2Rβ, which is also shared by the IL-15 receptor. It is constitutively expressed by NK cells and at lower levels by T cells, B cells, monocytes, and macrophages. The IL-2Rβ chain can combine with either the common γ subunit (γc, CD132) alone or with the γc subunit and the IL-2Rα subunit (CD25) to generate intermediate or high affinity IL-2 receptor complexes, respectively. CD122 expression levels can be upregulated by activation. The 5H4 Antibody does not block IL-2 binding to the IL-2 receptor. CD122 is expressed on murine, but not human, CD8+ Tregs involved in the maintenance of T cell homeostasis.\u003c\/p\u003e\n\n \n\n\u003cp\u003eSynonyms: IL-2R subunit beta| CD122| High affinity IL-2 receptor subunit beta| IL-2 receptor subunit beta| IL-2RB| Il2rb| Interleukin-2 receptor subunit beta| p70-75\u003c\/p\u003e\n\n \n\n\u003cp\u003eUniprot ID: P16297\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Mouse\u003c\/p\u003e\n\n\u003cp\u003eTested Application: FC\u003c\/p\u003e\n\n\u003cp\u003eRecommended Dilution: Each lot of this antibody is quality control tested by Flow cytometryometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1μg\/10⁶ cells in 100 μL volume].\u003c\/p\u003e\n\n\u003cp\u003eGene ID: 16185\u003c\/p\u003e\n\n \n\n \n\n\u003cp\u003eCategory: Flow cytometryometry Antibodies\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Fine Biotech","offers":[{"title":"25μg","offer_id":45346344796339,"sku":"F488-30213U-25","price":322.0,"currency_code":"CAD","in_stock":true},{"title":"100μg","offer_id":45346344829107,"sku":"F488-30213U-100","price":812.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/FineTest_Logo.png?v=1781809832","url":"https:\/\/afsbio.com\/products\/finetest%c2%ae488-anti-mouse-cd122-il-2rb-antibody-5h4-f488-30213u","provider":"AFSBio Inc.","version":"1.0","type":"link"}