{"product_id":"finetest®488-anti-mouse-cd274-pd-l1-antibody-10f-9g2-f488-30030","title":"FineTest®488 Anti-Mouse CD274\/PD-L1 Antibody (10F.9G2) - F488-30030","description":"\u003cp\u003eFineTest®488 Anti-Mouse CD274\/PD-L1 Antibody (10F.9G2)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50T, 100T\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: F488-30030-50, F488-30030-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eTarget: Mouse CD274\/PD\u003c\/p\u003e\n\n\u003cp\u003eForm: Liquid\u003c\/p\u003e\n\n\u003cp\u003eConjugation: FineTest®488\u003c\/p\u003e\n\n\u003cp\u003eConjugation Information: FineTest® 488 is designed to be excited by the Blue laser (488 nm) and detected using an optical filter centered near 520 nm (e.g., a 525\/40 nm bandpass filter).\u003c\/p\u003e\n\n \n\n \n\n\n\n\u003cp\u003eHost: Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 10F.9G2\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG2b, κ\u003c\/p\u003e\n\n\u003cp\u003eStorage: PBS with 0. 1% sodium azide, 1%BSA, pH 7.3, 2-8℃ for 12 months (Avoid repeated freeze \/ thaw cycles.)\u003c\/p\u003e\n\n\u003cp\u003eBackground: CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production.\u003c\/p\u003e\n\n \n\n\u003cp\u003eSynonyms: B7-H1|PD-L1|Programmed cell death ligand 1|B7 homolog 1|B7-H|B7H1|PDL1|PDCD1L1|PDCD1LG1\u003c\/p\u003e\n\n \n\n\u003cp\u003eUniprot ID: Q9EP73\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Mouse\u003c\/p\u003e\n\n\u003cp\u003eTested Application: FC\u003c\/p\u003e\n\n\u003cp\u003eRecommended Dilution: Volume per test: 5μL. Each lot of this antibody is quality control tested by Flow cytometryometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.\u003c\/p\u003e\n\n\u003cp\u003eGene ID: 60533\u003c\/p\u003e\n\n \n\n \n\n\u003cp\u003eCategory: Flow cytometryometry Antibodies\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Fine Biotech","offers":[{"title":"50T","offer_id":45346328314035,"sku":"F488-30030-50","price":218.4,"currency_code":"CAD","in_stock":true},{"title":"100T","offer_id":45346328346803,"sku":"F488-30030-100","price":358.4,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/FineTest_Logo.png?v=1781809832","url":"https:\/\/afsbio.com\/products\/finetest%c2%ae488-anti-mouse-cd274-pd-l1-antibody-10f-9g2-f488-30030","provider":"AFSBio Inc.","version":"1.0","type":"link"}