{"product_id":"fitc-rabbit-anti-human-tcr-γ-δ-monoclonal-antibody-a28422","title":"FITC Rabbit anti-Human TCR γ\/δ Monoclonal Antibody - A28422","description":"\u003cp\u003eFITC Rabbit anti-Human TCR γ\/δ Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 100T, 2 x 100T, 5 x 100T\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: A28422-100, A28422-200, A28422-500\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The γδ T-cell receptor (TCR) is a heterodimer composed of γ and δ chains, expressed on the T-cell surface and involved in antigen recognition. The engagement of the γδ TCR with antigen triggers the phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) within the CD3 chains. Unlike αβ T cells, human γδ T cells recognize and kill transformed cells in a manner unrestricted by human leukocyte antigen (HLA) presentation. γδ T lymphocytes primarily develop in the thymus, where their defining receptor is generated through RAG-mediated recombination of a relatively limited repertoire of variable (V), diversity (D), and joining (J) gene segments. In addition to the T-cell receptor, γδ T cells often express activating natural killer (NK) receptors, which bind to stress-induced surface molecules frequently expressed on malignant cells.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Monoclonal Antibodies\u003c\/p\u003e\n\n\u003cp\u003eApplication: FC\u003c\/p\u003e\n\n\u003cp\u003eCross Reactivity: Human\u003cbr\u003e\n  \u003cbr\u003e\nImmunogen: Recombinant protein (or fragment).\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 6964\/6965 Alternate Names: TCRD; TRD@; TCRDV1; TCRG; TRG@\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003ePurity: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at 2-8℃. Avoid freeze.|Buffer: PBS with 0.09% Sodium azide,0.2% BSA,pH7.3.\u003c\/p\u003e\n\n\u003cp\u003eRecommended Dilution: FC,5 μl per 10^6 cells in 100 μl volume\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Adaptive Immunity, Immunology\u003c\/p\u003e\n\n\u003cp\u003eNCBI Alias: TCR γ\/δ\u003c\/p\u003e\n\n\u003cp\u003eModifications: Unmodified\u003c\/p\u003e\n\n\u003cp\u003eConjugate: FITC. Ex:491nm. Em:516nm.\u003c\/p\u003e\n\n\u003cp\u003eClone Number Info: ARC79216\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"100T","offer_id":45189165187251,"sku":"A28422-100","price":221.2,"currency_code":"CAD","in_stock":true},{"title":"2 x 100T","offer_id":45189165220019,"sku":"A28422-200","price":403.2,"currency_code":"CAD","in_stock":true},{"title":"5 x 100T","offer_id":45189165252787,"sku":"A28422-500","price":935.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_7db559a4-472d-4cc6-befa-f2ee4497ba39.png?v=1766418895","url":"https:\/\/afsbio.com\/products\/fitc-rabbit-anti-human-tcr-%ce%b3-%ce%b4-monoclonal-antibody-a28422","provider":"AFSBio Inc.","version":"1.0","type":"link"}