CALIXAR’s FLAC6 reagent is a non-ionic amphiphilic detergent / surfactant with a lactobionamide head group and a fluorinated chain.
(4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluorononylamine) lactobionamide
Compound name: FLAC6
Catalogue number: FLAC6_50MG,FLAC6_100MG,FLAC6_250MG
Molec. Formula: C21H28F13NO11
CAS: nd
MW: 717.4 g/mol
pKa: na
Percent Composition: C, 35.16; H, 3.93; F, 34.43; N, 1.95; O, 24.53
Physical state: White powder
Purity (HPLC, 214nm): ≥98%
Retention time (RP18 HPLC)b: tR = 13.8 min
CMC: 0.56 mM (TS)
Exact mass: 717.1455
Stability: Store in <-20°C freezer for up to one year
Solubility Structure: Soluble in water (28mM), methanol and DMSO
CALIXAR uses a unique & custom-produced program
CALIXAR’s FLAC6 is manufactured into a powder form and is used in an aqueous solution or buffer. FLAC6 can be combined with biological substances (biological membranes).
Clients are able to use FLAC6 to produce lipid detergents, mixed micelles, and protein detergent micelles. FLAC6 empowers clients to extract, to solubilize and to stabilize native and functional membrane proteins in a solution.
FLAC6 is a very gentle non-ionic detergent to extract, solubilize and to stabilize native membrane proteins. As it is indifferent to ionic strength or pH variations it is ideal to extract, solubilize and stabilize particular membrane proteins of high medical relevance.
CALIXAR’s FLAC6 is non-ionic and therefore is not sensitive to ionic strength or pH variations. It is well conformed to extract, to solubilize and to stabilize specific membrane proteins.
CALIXAR’s FLAC6 extracts high-quality membrane proteins used for research, pharmaceutical discovery, and structural studies. FLAC6 is designed for pharmaceutical and biotechnology companies, as-well-as for academic teams (biochemists, structural biologists, pharmacologists, virologists) that are involved in the life science fields.
- Antibodies (including nanobodies, scaffold proteins, aptamers)
- Small molecules
- 3D Structures (cryoEM, XRay crystallography, NMR, SANS, SAXS)
- Drug discovery (Screening: HTS, FBDD, SBDD; Hit and lead validation)
- Antibody discovery (Immunization and display technologies)
- Clinical stage
ACS PUBLICATIONS
Lactobionamide Surfactants with Hydrogenated, Perfluorinated or Hemifluorinated Tails
Lebaupain F. et al. 2006