{"product_id":"flt-1-phospho-tyr1333-rabbit-polyclonal-antibody-es1485","title":"Flt-1 (phospho Tyr1333) Rabbit Polyclonal Antibody - ES1485","description":"\u003cp\u003eFlt-1 (phospho Tyr1333) Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES1485-50, ES1485-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.[provided by RefSeq, May 2009],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, IF, ELISA\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: FLT1, FLT, FRT, VEGFR1, Vascular endothelial growth factor receptor 1, VEGFR-1, Fms-like tyrosine kinase 1, FLT-1, Tyrosine-protein kinase FRT, Tyrosine-protein kinase receptor FLT, FLT, Vascular permeability factor receptor\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human VEGFR1 around the phosphorylation site of Tyr1333. AA range:1289-1338\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: Flt-1\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Phospho-Flt-1 (Y1333) Polyclonal Antibody detects endogenous levels of Flt-1 protein only when phosphorylated at Y1333.\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. IHC-p: 1:100-300 ELISA: 1\/20000. IF 1:100-300 Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Detected in normal lung, but also in placenta, liver, kidney, heart and brain tissues, Specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood monocytes, Isoform 2 is strongly expressed in placenta, Isoform 3 is expressed in corneal epithelial cells (at protein level), Isoform 3 is expressed in vascular smooth muscle cells (VSMC),\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 151kD\u003c\/p\u003e\n\n\u003cp\u003eFields: MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, HIF-1 signaling pathway, PI3K-Akt signaling pathway, Focal adhesion, Transcriptional misregulation in cancer, Rheumatoid arthritis\u003c\/p\u003e\n\n\u003cp\u003eFunction: Alternative Products: Additional isoforms seem to exist,Catalytic Activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate\u003cbr\u003e\nFunction: Receptor for VEGF, VEGFB and PGF. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand\/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. Isoform SFlt1 may have an inhibitory role in angiogenesis\u003cbr\u003e\nSimilarity: Belongs to the protein kinase superfamily. Tyr protein kinase family\u003cbr\u003e\nSimilarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1\/PDGF receptor subfamily\u003cbr\u003e\nSimilarity: Contains 1 protein kinase domain\u003cbr\u003e\nSimilarity: Contains 7 Ig-like C2-type (immunoglobulin-like) domains\u003cbr\u003e\nSubunit: Interacts in vitro with various phosphotyrosine-binding proteins, including PLC-gammas, PTPN11, GRB2, CRK and NCK1\u003cbr\u003e\nTissue Specificity: Mostly in normal lung, but also\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: [Isoform 1]: Cell membrane, Single-pass type I membrane protein Endosome Autophosphorylation promotes ubiquitination and endocytosis, [Isoform 2]: Secreted, [Isoform 3]: Secreted, [Isoform 4]: Secreted, [Isoform 5]: Cytoplasm, [Isoform 6]: Cytoplasm, [Isoform 7]: Cytoplasm\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: FLT1\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Vascular endothelial growth factor receptor 1\u003c\/p\u003e\n\n\u003cp\u003eMouse Gene ID: 14254\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: P35969\u003c\/p\u003e\n\n\u003cp\u003eRat Gene ID: 54251\u003c\/p\u003e\n\n\u003cp\u003eRat SwissProt Number: P53767\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46315184324787,"sku":"ES1485-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46315184357555,"sku":"ES1485-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies.jpg?v=1793190497","url":"https:\/\/afsbio.com\/products\/flt-1-phospho-tyr1333-rabbit-polyclonal-antibody-es1485","provider":"AFSBio Inc.","version":"1.0","type":"link"}