{"product_id":"fndc3b-polyclonal-antibody-e-ab-52260","title":"FNDC3B Polyclonal Antibody - E-AB-52260","description":"\u003cp\u003eFNDC3B Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-52260-60, E-AB-52260-120, E-AB-52260-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: FNDC3B\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: DKFZp686D14170 ; DKFZp762K137; Factor for adipocyte differentiation 104; FAD104; fibronectin type III domain containing 3B ; FLJ23399; HCV NS5A binding protein 37 ; MGC10002; NS5ABP37; PRO4979; YVTM2421\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Metabolism, Signal transduction, Stem cells\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplication: IHC, ELISA\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: Q53EP0\u003c\/p\u003e\n\n\u003cp\u003eBackground: Adipogenesis, the process of transforming pre-adipocytes into mature fat cells, is of particular interest due to the role adipocytes play in obesity and type II diabetes. Adipocytes have been shown to affect a variety of functions, including hemostasis, angiogenesis and energy balance, by secreting hormones and bioactive peptides. The FNDC3B protein, also designated FAD104 (factor for adipocyte differentiation 104) or HCV NS5A-binding protein 37, is expressed during early adipogenesis. Belonging to the FNDC3 family of proteins, FNDC3B is a 1, 204 amino acid protein that contains nine fibronectin type-III domains. FNDC3B-deficient mice die within one day of birth, suggesting that FNDC3B is crucial for postpartum survival. Mouse embryonic fibroblasts (MEFs) with loss of FNDC3B function displayed a reduction in stress fiber formation, indicating a role for FNDC3B in cell proliferation, adhesion, spreading and migration.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1.8 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Full length fusion protein\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Antigen affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: IHC 1:30-1:150, ELISA 1:5000-1:10000\u003c\/p\u003e\n\n \n\n \n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43133459988659,"sku":"E-AB-52260-60","price":200.2,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43133460021427,"sku":"E-AB-52260-120","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43133460054195,"sku":"E-AB-52260-200","price":558.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_c8d6f35b-7393-4a49-a950-8e85776475ff.png?v=1709899286","url":"https:\/\/afsbio.com\/products\/fndc3b-polyclonal-antibody-e-ab-52260","provider":"AFSBio Inc.","version":"1.0","type":"link"}