{"product_id":"frizzled-6-polyclonal-antibody-bt-ap03367","title":"Frizzled-6 Polyclonal Antibody - BT-AP03367","description":"\u003cp\u003eFrizzled-6 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP03367-20, BT-AP03367-50, BT-AP03367-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: FZD6 (frizzled class receptor 6) represents a member of the frizzled gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt\/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Stem Cells\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: FZD6\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IF, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Frizzled-6 Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 79274\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: O60353; Mouse: Q61089\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: FZD6; Frizzled-6; Fz-6; hFz6\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 8323\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45240315642035,"sku":"BT-AP03367-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45240315674803,"sku":"BT-AP03367-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45240315707571,"sku":"BT-AP03367-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_2c006e2c-d76e-419d-a199-3ab55cf98fac.png?v=1769406677","url":"https:\/\/afsbio.com\/products\/frizzled-6-polyclonal-antibody-bt-ap03367","provider":"AFSBio Inc.","version":"1.0","type":"link"}