{"product_id":"frizzled-6-polyclonal-antibody-ra25111","title":"Frizzled-6 Polyclonal Antibody - RA25111","description":"Frizzled-6 Polyclonal Antibody\n\nSizes: 50μL, 100μL\n\nCatalogue Numbers: RA25111-50, RA25111-100\n\nCitations, Manuals and MSDS Available upon request.\n\nBackground: frizzled class receptor 6 (FZD6) Homo sapiens This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt\/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.[provided by RefSeq, Aug 2011],\n\nCondition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\n\nStorage Instructions: -20°C\/1 year\n\nRecommended dilutions: Western Blot: 1\/500 - 1\/2000. Immunofluorescence: 1\/200 - 1\/1000. ELISA: 1\/5000. Not yet tested in other applications.\n\nAlternative Names: FZD6; Frizzled-6; Fz-6; hFz6\n\nApplications: WB; IF\/ICC; ELISA\n\nSpecies Cross-Reactivity: Human; Rat; Mouse\n\nGeneID (Human): 8323\n\nProtein MW (KDa): 80\n\nSWISS: O60353\n\nSource: Rabbit\n\nResearch Use Only","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45121284702387,"sku":"RA25111-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45121284735155,"sku":"RA25111-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_bae95857-ac7d-4f39-8147-6e64a6eb983c.png?v=1773346041","url":"https:\/\/afsbio.com\/products\/frizzled-6-polyclonal-antibody-ra25111","provider":"AFSBio Inc.","version":"1.0","type":"link"}