{"product_id":"frizzled-7-rabbit-pab-es2373","title":"Frizzled-7 rabbit pAb - ES2373","description":"\u003cp\u003eFrizzled-7 rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES2373-50, ES2373-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: frizzled class receptor 7 (FZD7) Homo sapiens Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq, Jul 2008],\u003c\/p\u003e \n\n\u003cp\u003eAlternate Name: FZD7; Frizzled-7; Fz-7; hFz7; FzE3\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; Flow Cyt; IF; ELISA\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000; Flow Cyt 1:50-200; IF\/ICC 1:100-500; ELISA 1:5000-20000\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Mouse\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human FZD7. AA range:45-94\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 64kD\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 8324\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: O75084\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Cell membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Associated to the plasma membrane in the presence of FZD7 and phosphatidylinositol 4, 5-bisphosphate (PIP2). Localized in recycling endosomes in other conditions.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45202072010931,"sku":"ES2373-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45202072043699,"sku":"ES2373-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_964f66da-a85d-4993-a9ee-fc67dd4965d7.png?v=1767121231","url":"https:\/\/afsbio.com\/products\/frizzled-7-rabbit-pab-es2373","provider":"AFSBio Inc.","version":"1.0","type":"link"}