{"product_id":"frizzled-8-polyclonal-antibody-bt-ap03369","title":"Frizzled-8 Polyclonal Antibody - BT-AP03369","description":"\u003cp\u003eFrizzled-8 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP03369-20, BT-AP03369-50, BT-AP03369-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This intronless gene FZD8 (frizzled class receptor 8) is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. FZD8 is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: FZD8\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC-p, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Frizzled-8 Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 73300\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q9H461; Mouse: Q61091; Rat: Q498S8\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: FZD8; Frizzled-8; Fz-8; hFz8\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 8325; Mouse: 14370; Rat: 1.0091e+008\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45240315838643,"sku":"BT-AP03369-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45240315871411,"sku":"BT-AP03369-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45240315904179,"sku":"BT-AP03369-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_f96b9aa2-93ab-4ab0-ab66-61a1f6d96f27.png?v=1769406680","url":"https:\/\/afsbio.com\/products\/frizzled-8-polyclonal-antibody-bt-ap03369","provider":"AFSBio Inc.","version":"1.0","type":"link"}