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FTAC6 Reagent - 250mg

FTAC6 Reagent - 250mg

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$236.21 CAD
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CALIXAR’s FTAC6 Reagent is a non-ionic detergent that is primarily used to extract, solubilize and stabilize GPCRs, Ion channels, and Transporters.

S-(poly(tris(hydroxymethyl)acrylamidomethane)-(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorothiooctyl) DPn=6

Compound name: FTAC6

Catalogue number: FTAC6_250MG

Molec. Formula: C6F13CH2CH2CH2

CAS: nd

MW: ≈1400 g/mol

pKa: na​

Percent Composition: na

Physical state: White powder

Purity (HPLC, 214nm): nd

Retention time (RP18 HPLC)b: tR = 10.5 min min

CMC: 0.37 mM

Exact mass​: nd

Stability: Store in <-20°C freezer for up to one year

Solubility Structure: Soluble in water (18.5mM), methanol and DMSO

 

 

CALIXAR used a novel & custom-produced method 

CALIXAR’s FTAC6 is a very soft detergent used to stabilize native membrane proteins. FTAC6 is non-ionic and therefore not sensitive to ionic strength or pH variations is well adapted to stabilize many different specific membrane proteins. Due to the fluorinated chain, FTAC6 is poorly delipidating towards membrane proteins.

FTAC6 can improve the production of lipid detergents, mixed micelles, and protein detergent micelles. FTAC6 allows for the stabilization of native and functional membrane proteins in a solution.

FTAC6 is provided in powder form and will be used in an aqueous solution or buffer and can also be mixed within biological materials (biological membranes).

 

CALIXAR’s FTAC6 is non-ionic and consequently not sensitive to ionic strength or pH fluctuations and is able to stabilize specific membrane proteins. Due to the fluorinated chain, FTAC6 does not solubilize lipid membranes. 

 

CALIXAR’s FTAC6 is a high-quality detergent / reagent used for research and pharmaceutical discovery projects. CALIXAR's structural studies and are adapted for use in biotechnology companies, as well as for academic teams (biochemists, structural biologists, pharmacologists, virologists) involved in the life science fields.

 

  • Antibodies (including nanobodies, scaffold proteins, aptamers)
  • Small molecules
  • 3D Structures (cryoEM, XRay crystallography, NMR, SANS, SAXS)
  • Drug discovery (Screening: HTS, FBDD, SBDD; Hit and lead validation)
  • Antibody discovery (Immunization and display technologies)
  • Clinical stage (drug validation on reliable native DDLAC)

References

FEBS LETTERS

New tensio-active molecules stabilize a human G protein-coupled receptor in solution.

Damian, M. et al. 2007

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Functional studies of membrane-bound and purified human Hedgehog receptor Patched expressed in yeast.

Joubert O. et al. 2009