{"product_id":"fyb-monoclonal-antibody-mb66533","title":"FYB Monoclonal Antibody - MB66533","description":"\u003cp\u003eFYB Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μl, 100μl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: MB66533-50, MB66533-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: ADAP (adhesion and degranμlation-promoting adaptor protein\/SLAP-130\/Fyb) is an SH3 domain-containing adaptor protein expressed by T cells, NK cells, and myeloid cells. There are two isoforms of ADAP with predicted molecμlar weights of 85 kDa and 90 kDa, but observed molecμlar weights of 120 kDa and 130 kDa. ADAP was identified as an adaptor protein that interacts with SLP-76 following T cell receptor (TCR) stimμlation and was subsequently found to be important for several aspects of T cell activation. For example, ADAP is required for integrin-dependent clustering, signaling, and adhesion. In addition, ADAP interacts with CARMA1 and facilitates assembly of the CARMA1-Bcl10-MALT1 complex important for NF-κB activation downstream of TCR activation. Finally, following binding of a T cell to an antigen presenting cell, ADAP forms a ring at the immunological synapse that recruits dynein to enable microtubμle-organizing center polarization.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Primary Antibody\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: SLAP130, FYN-binding protein, Adhesion and degranμlation promoting adaptor protein, ADAP, FYB-120\/130, p120\/p130, FYN-T-binding protein, SLAP-130, SLP-76-associated phosphoprotein\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodification\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant human FYB protein fragments expressed in E.coli.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB (1\/500 - 1\/1000)\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was purified by immunogen affinity chromatography.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Recognizes endogenous levels of FYB protein.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: ~ 120 kDa\u003c\/p\u003e\n\n\u003cp\u003ePathway: T Cell Receptor Signaling\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSwissProt: O15117\u003c\/p\u003e\n\n\u003cp\u003eProduct: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"50μl","offer_id":45946408337587,"sku":"MB66533-50","price":274.5,"currency_code":"CAD","in_stock":true},{"title":"100μl","offer_id":45946408370355,"sku":"MB66533-100","price":457.5,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Bioworld_Antibody_Image_6ca33534-2486-4e91-ac84-9e0d75778258.jpg?v=1788363539","url":"https:\/\/afsbio.com\/products\/fyb-monoclonal-antibody-mb66533","provider":"AFSBio Inc.","version":"1.0","type":"link"}