{"product_id":"fzd6-polyclonal-antibody-e-ab-63423","title":"FZD6 Polyclonal Antibody - E-AB-63423","description":"\u003cp\u003eFZD6 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-63423-60, E-AB-63423-120, E-AB-63423-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: FZD6\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: FZD6; FZ-6; FZ6; HFZ6; NDNC10\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Stem Cells\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: O60353\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt\/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human FZD6 (NP_003497.2).\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB \t1:1000-1:2000\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 75kDa\/79kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 79kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146287808691,"sku":"E-AB-63423-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146287841459,"sku":"E-AB-63423-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146287874227,"sku":"E-AB-63423-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_5e78652e-a559-4009-a6df-eceec6e71376.png?v=1710293043","url":"https:\/\/afsbio.com\/products\/fzd6-polyclonal-antibody-e-ab-63423","provider":"AFSBio Inc.","version":"1.0","type":"link"}