{"product_id":"fzr1-monoclonal-antibody-mb67249","title":"FZR1 Monoclonal Antibody-MB67249","description":"\u003cp\u003eFZR1 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: MB67249-50, MB67249-100\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eProduct: Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q9UM11\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB (1\/500 - 1\/1000)\u003c\/p\u003e\n\n\u003cp\u003eBackground: Substrate-specific adapter for the anaphase promoting complex\/cyclosome (APC\/C) E3 ubiquitin-protein ligase complex. Associates with the APC\/C in late mitosis, in replacement of CDC20, and activates the APC\/C during anaphase and telophase. The APC\/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1\/S transition FZR1 is phosphorylated, leading to its dissociation from the APC\/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC\/C leads to the ubiquitination of PLK1, preventing entry into mitosis. Acts as an adapter for APC\/C to target the DNA-end resection factor RBBP8\/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8\/CtIP protein turnover, may play a role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR).\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: This antibody is purified through a protein G column.\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Recognizes endogenous levels of FZR1 protein.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot analysis of FZR1 expression in 293T (A), Hela (B) whole cell lysates.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 54 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: CDH1; FYR; FZR; KIAA1242; Fizzy-related protein homolog; Fzr; CDC20-like protein 1; Cdh1\/Hct1 homolog; hCDH1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human FZR1. The exact sequence is proprietary.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42906420609203,"sku":"MB67249-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42906420641971,"sku":"MB67249-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_f476ae87-c748-46da-93ac-912d1ac671e8.jpg?v=1702919282","url":"https:\/\/afsbio.com\/products\/fzr1-monoclonal-antibody-mb67249","provider":"AFSBio Inc.","version":"1.0","type":"link"}