{"product_id":"g6pc-polyclonal-antibody-e-ab-52080","title":"G6PC Polyclonal Antibody - E-AB-52080","description":"\u003cp\u003eG6PC Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-52080-60, E-AB-52080-120, E-AB-52080-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: G6PC\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: AW107337; G-6-Pase; G6Pase; G6Pase-alpha; g6pc; G6PC; G6PT; Glucose-6-phosphatase alpha; Glucose-6-phosphatase; GSD1; GSD1a; MGC163350; MGC93613; RP23-281C18.19\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Cell Biology, Metabolism\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: IHC, ELISA\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: P35575\u003c\/p\u003e\n\n\u003cp\u003eBackground: Glucose-6-phosphatase (G6Pase) is a multi-subunit integral membrane protein of the endoplasmic reticulum that is composed of a catalytic subunit and transporters for G6P, inorganic phosphate, and glucose. This gene (G6PC) is one of the three glucose-6-phosphatase catalytic-subunit-encoding genes in human: G6PC, G6PC2 and G6PC3. Glucose-6-phosphatase catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate and is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Mutations in this gene cause glycogen storage disease type I (GSD1). This disease, also known as von Gierke disease, is a metabolic disorder characterized by severe hypoglycemia associated with the accumulation of glycogen and fat in the liver and kidneys.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 2.04 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide of human G6PC\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Antigen affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: IHC 1:70-1:350, ELISA 1:5000-1:10000\u003c\/p\u003e\n\n \n\n \n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43133445898419,"sku":"E-AB-52080-60","price":200.2,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43133445931187,"sku":"E-AB-52080-120","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43133445963955,"sku":"E-AB-52080-200","price":558.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_d82866ec-2356-4485-a150-a5888be508db.png?v=1709899123","url":"https:\/\/afsbio.com\/products\/g6pc-polyclonal-antibody-e-ab-52080","provider":"AFSBio Inc.","version":"1.0","type":"link"}