{"product_id":"gabaa-rβ1-phospho-s434-polyclonal-antibody-bs4078","title":"GABAA Rβ1 (phospho-S434) Polyclonal Antibody-BS4078","description":"\u003cp\u003eGABAA Rβ1 (phospho-S434) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS4078-50, BS4078-100\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P18505\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eGABAA Rβ1 (phospho-S434) Polyclonal Antibody-BS4078\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB: 1:500~1:1000\u003cbr\u003e\nIHC: 1:50~1:200\u003c\/p\u003e\n\n\u003cp\u003eBackground: GAD-65 and GAD-67, glutamate decarboxylases, function to catalyze the production of GABA (gamma-aminobutyric acid). In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl- conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels, however, they are structurally and functionally distinct. Members of the GABAA receptor family include GABAA Rα1-6, GABAA R β1-3, GABAA Rγ1-3, GABAA Rδ, GABAA Rε, GABAA Rρ1 and GABAA Rρ2. The GABAB family is composed of GABAB R1α and GABAB R1β. GABA transporters have also been identified and include GABA T-1, GABA T-2 and GABA T-3 (also designated GAT-1, -2, and -3). The GABA transporters function to terminate GABA action.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: p-GABAA Rβ1 (S434) polyclonal antibody detects endogenous levels of GABAA Rβ1 protein when phosphorylated at Ser434.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 54 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot (WB) analysis of p-GABAA Rβ1 (S434) polyclonal antibody at 1:500 dilution\u003cbr\u003e\n Lane 1: HEK293T whole cell lysate\u003cbr\u003e\n Lane 2: Raw264.7 whole cell lysate\u003cbr\u003e\n Lane 3: Rat brain tissue lysate, Immunohistochemistry (IHC) analyzes of p-GABAA Rβ1 (S434) pAb in paraffin-embedded human colorectal carcinoma tissue at 1:50.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Gamma-aminobutyric acid receptor subunit beta-1; GABA(A) receptor subunit beta-1; GABRB1; GABAARβ1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic phosphopeptide derived from human GABAA Rβ1 around the phosphorylation site of Serine 434.\u003c\/p\u003e\n\n\u003cp\u003eModification: Phosphorylation\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42957296042163,"sku":"BS4078-50","price":276.71,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42957296074931,"sku":"BS4078-100","price":490.83,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_ddb9d37b-10b1-40be-b4fd-dbe87dc9f13e.jpg?v=1705144498","url":"https:\/\/afsbio.com\/products\/gabaa-r%ce%b21-phospho-s434-polyclonal-antibody-bs4078","provider":"AFSBio Inc.","version":"1.0","type":"link"}