{"product_id":"gad67-polyclonal-antibody-bs90553","title":"GAD67 Polyclonal Antibody-BS90553","description":"\u003cp\u003eGAD67 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS90553-50, BS90553-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q99259(Human) P48318(Mouse) P18088(Rat)\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB IP\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB:1:500-1:1,000\u003cbr\u003e\nIP:1:50-1:100\u003c\/p\u003e\n\n\u003cp\u003eBackground: There are two forms of glutamic acid decarboxylases (GADs) that are found in the brain: GAD-65 (also known as GAD2) and GAD-67 (also known as GAD1, GAD or SCP). GAD-65 and GAD-67 are members of the group II decarboxylase family of proteins and are responsible for catalyzing the rate limiting step in the production of GABA (g-aminobutyric acid) from L-glutamic acid. Although both GADs are found in the brain, GAD-65 localizes to synaptic vesicle membranes in nerve terminals, while GAD-67 is distributed throughout the cell. GAD-67 is responsible for the basal levels of GABA synthesis. In the case of a heightened demand for GABA in neurotransmission, GAD-65 will transiently activate to assist in GABA production. The loss of GAD-65 is detrimental and can impair GABA neurotransmission, however the loss of GAD-67 is lethal. Due to alternative splicing, two isoforms exist for GAD-67, the predominant GAD-67 form and the minor GAD-25 form. GAD-25 is not expressed in brain but can be found in a variety of endocrine tissues.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: ProA affinity purified\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot analysis of GAD67 on Hela cellsLysates using anti-GAD67 antibody at 1\/500 dilution.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: 67 kDa\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: GAD67 polyclonal antibody detects endogenous levels of GAD67 protein.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: GAD-67, 67 kDa glutamic acid decarboxylase, CPSQ1, DCE1, DCE1, EC 4.1.1.15, FLJ45882, GAD 67, GAD, GAD-67, GAD1, Glutamate decarboxylase 1 (brain, 67kDa), Glutamate decarboxylase 1, Glutamate decarboxylase 1 brain 67kD, Glutamate decarboxylase 1 brain 67kDa, Glutamate decarboxylase 67 kDa isoform, Glutamate decarboxylase, brain, 67-KD, OTTHUMP00000041055, SCP,\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: recombinant protein\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42939199979699,"sku":"BS90553-50","price":415.38,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42939200012467,"sku":"BS90553-100","price":640.78,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_b73e8ba0-7485-4a12-8c8a-4437ba3e63c8.jpg?v=1704545004","url":"https:\/\/afsbio.com\/products\/gad67-polyclonal-antibody-bs90553","provider":"AFSBio Inc.","version":"1.0","type":"link"}