{"product_id":"gak-polyclonal-antibody-ra25198","title":"GAK Polyclonal Antibody - RA25198","description":"GAK Polyclonal Antibody\n\nSizes: 50μL, 100μL\n\nCatalogue Numbers: RA25198-50, RA25198-100\n\nCitations, Manuals and MSDS Available upon request.\n\nBackground: cyclin G associated kinase (GAK) Homo sapiens In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the 'cyclin box.' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015],\n\nCondition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\n\nStorage Instructions: -20°C\/1 year\n\nRecommended dilutions: Western Blot: 1\/500 - 1\/2000. Immunohistochemistry: 1\/100 - 1\/300. Immunofluorescence: 1\/200 - 1\/1000. ELISA: 1\/5000. Not yet tested in other applications.\n\nAlternative Names: GAK; Cyclin-G-associated kinase\n\nApplications: WB; IHC-p; IF\/ICC; ELISA\n\nSpecies Cross-Reactivity: Human; Mouse\n\nGeneID (Human): 2580\n\nProtein MW (KDa): 144\n\nSWISS: O14976\n\nSource: Rabbit\n\nResearch Use Only","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45121289453747,"sku":"RA25198-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45121289486515,"sku":"RA25198-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_7a9eacf6-ed31-4f10-aa5d-d39676e91e03.png?v=1773346092","url":"https:\/\/afsbio.com\/products\/gak-polyclonal-antibody-ra25198","provider":"AFSBio Inc.","version":"1.0","type":"link"}