{"product_id":"galectin-3-monoclonal-antibody-mb65926","title":"Galectin 3 Monoclonal Antibody-MB65926","description":"\u003cp\u003eGalectin 3 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: MB65926-50, MB65926-100\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eProduct: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P17931\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB (1\/2000 - 1\/5000)\u003c\/p\u003e\n\n\u003cp\u003eBackground: Galectins are a family of β-galactose binding proteins that are characterized by an affinity for poly-N-acetyllactosamine-enriched glycoconjugates and a carbohydrate-binding site. Members of the galectin family have been implicated in a variety of biological functions including cell adhesion, growth regulation, cytokine production, T-cell apoptosis, and immune responses.Galectin-3\/LGALS3 is involved in several diverse biological functions. Galectin-3\/LGALS3 binds IgE. Galectin-3\/LGALS3 is an unusual protein in that it can be found both extracellularly and intracellularly. Intracellularly, galectin-3\/LGALS3 can localize to the cytoplasm, nucleus, or both, depending on cell type and experimental conditions. Nuclear galectin-3\/LGALS3 has been identified as a pre-mRNA splicing factor. Galectin-3\/LGALS3 production has been shown to increase during inflammation and in obesity, and the protein itself can have an inflammatory effect under certain conditions. Galectin-3\/LGALS3 forms a complex with α3, β1 integrin to act as a surface receptor on endothelial cells for the NG2 proteoglycan, which triggers cell motility and angiogenesis. In addition to these functions, galectin-3\/LGALS3 is also a required factor for the terminal differentiation of epithelial cells.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Recognizes endogenous levels of Galectin 3 protein.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot analysis of Galectin 3 expression in MCF7 (A), NIH3T3 (B) whole cell lysates.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 26 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: MAC2; Galectin-3; Gal-3; 35 kDa lectin; Carbohydrate-binding protein 35; CBP 35; Galactose-specific lectin 3; Galactoside-binding protein; GALBP; IgE-binding protein; L-31; Laminin-binding protein; Lectin L-29; Mac-2 antigen\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant protein corresponding to human Galectin 3.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42908743401651,"sku":"MB65926-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42908743434419,"sku":"MB65926-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_cd6f7e24-36c5-4076-bfa6-92cae2a5e7b8.jpg?v=1703006542","url":"https:\/\/afsbio.com\/products\/galectin-3-monoclonal-antibody-mb65926","provider":"AFSBio Inc.","version":"1.0","type":"link"}