{"product_id":"galt2-rabbit-polyclonal-antibody-es16271","title":"GALT2 Rabbit Polyclonal Antibody - ES16271","description":"\u003cp\u003eGALT2 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES16271-50, ES16271-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the glycosyltransferase 2 protein family. Members of this family initiate mucin-type O-glycoslation of peptides in the Golgi apparatus. The encoded protein may be involved in O-linked glycosylation of the immunoglobulin A1 hinge region. This gene may influence triglyceride levels, and may be involved Type 2 diabetes, as well as several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: Polypeptide N-acetylgalactosaminyltransferase 2 (EC 2.4.1.41) (Polypeptide GalNAc transferase 2) (GalNAc-T2) (pp-GaNTase 2) (Protein-UDP acetylgalactosaminyltransferase 2) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2) [Cleaved into: Polypeptide N-acetylgalactosaminyltransferase 2 soluble form]\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from human GALT2 AA range: 30-80\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: GALT2\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: This antibody detects endogenous levels of GALT2 at Human\/Mouse\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.194% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Widely expressed,\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 65kD\u003c\/p\u003e\n\n\u003cp\u003eFields: Mucin type O-glycan biosynthesis, Other types of O-glycan biosynthesis, Metabolic pathways\u003c\/p\u003e\n\n\u003cp\u003eFunction: Catalytic Activity: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide\u003cbr\u003e\nCofactor: Calcium\u003cbr\u003e\nCofactor: Manganese\u003cbr\u003e\nDomain: The ricin B-type lectin domain binds to GalNAc and contributes to the glycopeptide specificity\u003cbr\u003e\nDomain: There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal\/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding\u003cbr\u003e\nFunction: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Golgi apparatus, Golgi stack membrane, Single-pass type II membrane protein Secreted Resides preferentially in the trans and medial parts of the Golgi stack A secreted form also exists\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: GALNT2\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: GALT2\u003c\/p\u003e\n\n\u003cp\u003eMouse Gene ID: 108148\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q6PB93\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46315392893107,"sku":"ES16271-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46315392925875,"sku":"ES16271-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies.jpg?v=1793190497","url":"https:\/\/afsbio.com\/products\/galt2-rabbit-polyclonal-antibody-es16271","provider":"AFSBio Inc.","version":"1.0","type":"link"}