{"product_id":"gamma-catenin-monoclonal-antibody-mb66888","title":"Gamma-catenin Monoclonal Antibody - MB66888","description":"\u003cp\u003eGamma-catenin Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μl, 100μl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: MB66888-50, MB66888-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: Also known as plakoglobin, 纬-catenin is a member of the Armadillo family of signaling molecμles, which includes 尾-catenin and the聽Drosophila聽protein armadillo . This family of proteins is involved in Wnt signaling, which is important in embryonic development and in tumorigenesis . Although the two vertebrate proteins 尾- and 纬-catenin display sequence homology, 纬-catenin likely plays a role distinct from that of 尾-catenin . 纬-catenin localizes to desmosomes and adherens junctions, both sites of intercellμlar adhesion, and interacts with the cytoplasmic domains of classical and desmosomal cadherins. Interaction of 纬- or 尾-catenin with 伪-catenin, desmoplakin and other junction proteins provides a link between intercellμlar junctions and the actin and intermediate filament cytoskeleton. Maintenance and\/or modification of this link is vital for control of cell adhesion and migration . 纬-catenin is modified by phosphorylation, affecting both adhesion and 尾-catenin dependent transcription , and by and O-glycosylation, affecting adhesion . Recent evidence suggests that 纬-catenin regμlates desmosomal adhesion in response to growth factor stimμlation .\u003c\/p\u003e\n\n\u003cp\u003eCategory: Primary Antibody\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: CTNNG, DP3, Junction plakoglobin, Catenin gamma, Desmoplakin III, Desmoplakin-3\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodification\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Gamma-catenin. The exact sequence is proprietary.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB (1\/500 - 1\/1000)\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Recognizes endogenous levels of Gamma-catenin protein.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: ~ 83 kDa\u003c\/p\u003e\n\n\u003cp\u003ePathway: Adherens Junction signaling\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSwissProt: P14923\u003c\/p\u003e\n\n\u003cp\u003eProduct: Mouse IgG3. Supplied in crude ascites with 0.01% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"50μl","offer_id":45946157236403,"sku":"MB66888-50","price":274.5,"currency_code":"CAD","in_stock":true},{"title":"100μl","offer_id":45946157269171,"sku":"MB66888-100","price":457.5,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Bioworld_Antibody_Image_6ca33534-2486-4e91-ac84-9e0d75778258.jpg?v=1788363539","url":"https:\/\/afsbio.com\/products\/gamma-catenin-monoclonal-antibody-mb66888","provider":"AFSBio Inc.","version":"1.0","type":"link"}