{"product_id":"gch1-polyclonal-antibody-bt-ap15708","title":"GCH1 Polyclonal Antibody - BT-AP15708","description":"\u003cp\u003eGCH1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP15708-20, BT-AP15708-50, BT-AP15708-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme.\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Cell biology; Metabolism; Neuroscience; Signal transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: GCH1\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: GTP cyclohydrolase 1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P30793; Mouse: Q05915; Rat: P22288\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: GTP cyclohydrolase 1;EC 3.5.4.16;GTP cyclohydrolase I;GTP-CH-I\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 2643\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239147593907,"sku":"BT-AP15708-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239147626675,"sku":"BT-AP15708-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239147659443,"sku":"BT-AP15708-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_db4cfeeb-4f91-43b0-aca6-3c89d7e3cf0f.png?v=1769389782","url":"https:\/\/afsbio.com\/products\/gch1-polyclonal-antibody-bt-ap15708","provider":"AFSBio Inc.","version":"1.0","type":"link"}