{"product_id":"gcsc-γ-rabbit-pab-es2414","title":"GCSc-γ rabbit pAb - ES2414","description":"\u003cp\u003eGCSc-γ rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES2414-50, ES2414-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.[provided by RefSeq, Oct 2010],\u003c\/p\u003e \n\n\u003cp\u003eAlternate Name: GCLC; GLCL; GLCLC; Glutamate--cysteine ligase catalytic subunit; GCS heavy chain; Gamma-ECS; Gamma-glutamylcysteine synthetase\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; ELISA\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. ELISA: 1\/10000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Mouse; Rat\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human GCSc-gamma. AA range:266-315\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 73kD\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 2729\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: P48506\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: cytosol, integral component of membrane, glutamate-cysteine ligase complex,\u003c\/p\u003e \n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45202075091123,"sku":"ES2414-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45202075123891,"sku":"ES2414-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_8fee65c8-bb1f-4108-b0af-5eab88334300.png?v=1767121289","url":"https:\/\/afsbio.com\/products\/gcsc-%ce%b3-rabbit-pab-es2414","provider":"AFSBio Inc.","version":"1.0","type":"link"}