{"product_id":"gdnf-polyclonal-antibody-bt-ap09466","title":"GDNF Polyclonal Antibody - BT-AP09466","description":"\u003cp\u003eGDNF Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP09466-20, BT-AP09466-50, BT-AP09466-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The recombinant form of this protein, a highly conserved neurotrophic factor, was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. This protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Mutations in this gene may be associated with Hirschsprung disease and Tourette syndrome. This gene encodes multiple protein isoforms that may undergo similar proteolytic\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Developmental biology; Neuroscience\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: GDNF\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Glial cell line-derived neurotrophic factor\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P39905; Mouse: P48540; Rat: Q07731\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Glial cell line-derived neurotrophic factor;hGDNF;Astrocyte-derived trophic factor;ATF\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 2668\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239149002931,"sku":"BT-AP09466-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239149035699,"sku":"BT-AP09466-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239149068467,"sku":"BT-AP09466-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_23e48901-4ddd-4c62-b4bc-adf42172264f.png?v=1769389797","url":"https:\/\/afsbio.com\/products\/gdnf-polyclonal-antibody-bt-ap09466","provider":"AFSBio Inc.","version":"1.0","type":"link"}