{"product_id":"gfralpha-1-polyclonal-antibody-bt-ap03553","title":"GFRAlpha-1 Polyclonal Antibody - BT-AP03553","description":"\u003cp\u003eGFRAlpha-1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP03553-20, BT-AP03553-50, BT-AP03553-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: GFRA1 encodes a member of the glial cell line-derived neurotrophic factor receptor (GDNFR) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature receptor. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. This receptor is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Neuroscience\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: GFRA1\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC-p, WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: GFRalpha-1 Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 51456\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P56159; Mouse: P97785; Rat: Q62997\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: GFRA1; GDNFRA; RETL1; TRNR1; GDNF family receptor alpha-1; GDNF receptor alpha-1; GDNFR-alpha-1; GFR-alpha-1; RET ligand 1; TGF-beta-related neurotrophic factor receptor 1\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 2674; Mouse: 14585; Rat: 25454\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45240329568435,"sku":"BT-AP03553-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45240329601203,"sku":"BT-AP03553-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45240329633971,"sku":"BT-AP03553-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_291f92d7-2565-4206-9c77-1ec88ba8894a.png?v=1769406888","url":"https:\/\/afsbio.com\/products\/gfralpha-1-polyclonal-antibody-bt-ap03553","provider":"AFSBio Inc.","version":"1.0","type":"link"}