{"product_id":"ghr-polyclonal-antibody-e-ab-90941","title":"GHR Polyclonal Antibody - E-AB-90941","description":"\u003cp\u003eGHR Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-90941-60, E-AB-90941-120, E-AB-90941-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: GHR\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: GHR; GHBP; GHIP\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Cell Biology, Developmental Biology, Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: P10912\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human GHR\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.01% thiomersal, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-1:2000\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 33kDa\/34kDa\/69kDa\/71kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 72kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146580492467,"sku":"E-AB-90941-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146580525235,"sku":"E-AB-90941-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146580558003,"sku":"E-AB-90941-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_321d724c-6abe-4fce-a714-1c1f58e60bc6.png?v=1710297830","url":"https:\/\/afsbio.com\/products\/ghr-polyclonal-antibody-e-ab-90941","provider":"AFSBio Inc.","version":"1.0","type":"link"}