{"product_id":"ghr-rabbit-pab-es4303","title":"GHR rabbit pAb - ES4303","description":"\u003cp\u003eGHR rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES4303-50, ES4303-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011],\u003c\/p\u003e \n\n\u003cp\u003eAlternate Name: GHR; Growth hormone receptor; GH receptor; Somatotropin receptor\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; ELISA\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. ELISA: 1\/10000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Mouse; Rat\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from the N-terminal region of human GHR. AA range:21-70\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 140kD\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 2690\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: P10912\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Cell membrane; Single-pass type I membrane protein. On growth hormone binding, GHR is ubiquitinated, internalized, down-regulated and transported into a degradative or non-degradative pathway.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein. Remains fixed to the cell membrane and is not internalized.; [Growth hormone-binding protein]: Secreted. Complexed to a substantial fraction of circulating GH.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45202189484211,"sku":"ES4303-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45202189516979,"sku":"ES4303-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_5c24c124-41d9-4296-85e6-662246e0e398.png?v=1767123864","url":"https:\/\/afsbio.com\/products\/ghr-rabbit-pab-es4303","provider":"AFSBio Inc.","version":"1.0","type":"link"}