{"product_id":"gitr-monoclonal-antibody-bt-mca4444","title":"GITR Monoclonal Antibody - BT-MCA4444","description":"\u003cp\u003eGITR Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA4444-50, BT-MCA4444-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Others\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: GITR\u003c\/p\u003e\n\n\u003cp\u003eApplications: FCM\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 6H8B9\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG1\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: GITR\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of human GITR (AA: 184-241) expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Purified antibody in PBS with 0.05% sodium azide\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 26kDa\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Q9Y5U5\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: TNFRSF18, AITR, CD357, GITR-D\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 8784\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238536503475,"sku":"BT-MCA4444-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238536536243,"sku":"BT-MCA4444-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_54f891e6-6012-43e5-9a56-db780975530d.png?v=1769382336","url":"https:\/\/afsbio.com\/products\/gitr-monoclonal-antibody-bt-mca4444","provider":"AFSBio Inc.","version":"1.0","type":"link"}