{"product_id":"gk1-rabbit-polyclonal-antibody-es2428","title":"GK1 Rabbit Polyclonal Antibody - ES2428","description":"\u003cp\u003eGK1 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES2428-50, ES2428-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene belongs to the FGGY kinase family. This protein is a key enzyme in the regulation of glycerol uptake and metabolism. It catalyzes the phosphorylation of glycerol by ATP, yielding ADP and glycerol-3-phosphate. Mutations in this gene are associated with glycerol kinase deficiency (GKD). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IF, ELISA\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: GK, Glycerol kinase, GK, Glycerokinase, ATP:glycerol 3-phosphotransferase\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human GK. AA range:461-510\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: GK1\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: GK1 Polyclonal Antibody detects endogenous levels of GK1 protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. Immunofluorescence: 1\/200 - 1\/1000. ELISA: 1\/20000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Highly expressed in the liver, kidney and testis, Isoform 2 and isoform 3 are expressed specifically in testis and fetal liver, but not in the adult liver,\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 57kD\u003c\/p\u003e\n\n\u003cp\u003eFields: Glycerolipid metabolism, Metabolic pathways, PPAR signaling pathway\u003c\/p\u003e\n\n\u003cp\u003eFunction: Catalytic Activity: ATP + glycerol = ADP + sn-glycerol 3-phosphate\u003cbr\u003e\nCaution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data\u003cbr\u003e\nDisease: Defects in GK are the cause of GK deficiency (GKD) [MIM: 307030]. This disease can be either symptomatic with episodic metabolic and CNS decompensation or asymptomatic with hyperglycerolemia and hyperglyceroluria only\u003cbr\u003e\nFunction: Key enzyme in the regulation of glycerol uptake and metabolism\u003cbr\u003e\nPathway: Polyol metabolism, glycerol degradation via glycerol kinase pathway, sn-glycerol 3-phosphate from glycerol: step 1\/1\u003cbr\u003e\nSimilarity: Belongs to the FGGY kinase family\u003cbr\u003e\nSubcellular Location: In sperm and fetal tissues, the majority of the enzyme is bound to mitochondria, but in adult tissues, such as liver found in the cytoplasm\u003cbr\u003e\nTissue Specificity: Highly expressed in the liver, kidney and testis\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Mitochondrion outer membrane, Peripheral membrane protein, Cytoplasmic side Cytoplasm In sperm and fetal tissues, the majority of the enzyme is bound to mitochondria, but in adult tissues, such as liver found in the cytoplasm\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: GK\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Glycerol kinase\u003c\/p\u003e\n\n\u003cp\u003eMouse Gene ID: 14933\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q64516\u003c\/p\u003e\n\n\u003cp\u003eRat Gene ID: 79223\u003c\/p\u003e\n\n\u003cp\u003eRat SwissProt Number: Q63060\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46314210361523,"sku":"ES2428-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46314210394291,"sku":"ES2428-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies_d75295e2-ffc1-4e0f-a3e7-87715c8983a9.jpg?v=1793190507","url":"https:\/\/afsbio.com\/products\/gk1-rabbit-polyclonal-antibody-es2428","provider":"AFSBio Inc.","version":"1.0","type":"link"}